Analytical Data
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Gene name
IHPK1
- Application
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Alternative Names
IP6K1; PiUS; Inositol hexakisphosphate kinase 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92551
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Expression Region
Met1~Gly300
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Molecular Weight
38.0kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IHPK1 (Inositol Hexakisphosphate Kinase 1) is an enzyme that plays a crucial role in the metabolism of inositol phosphates, which are important signaling molecules involved in various cellular processes such as proliferation, differentiation, and apoptosis. The study of IHPK1 has gained momentum due to its implications in various physiological and pathological conditions, including cancer and metabolic disorders. Research has shown that IHPK1 can influence cellular signaling pathways by regulating levels of inositol hexakisphosphate (InsP6) and other inositol phosphates, which can affect various downstream targets. Additionally, IHPK1 is linked to the control of cellular energy homeostasis and stress responses. Given its potential role as a therapeutic target, understanding the structure and function of IHPK1 through recombinant protein studies is essential for elucidating its mechanisms of action. Recombinant IHPK1 protein has been produced to facilitate biochemical assays that investigate its enzymatic activity, substrate specificity, and interaction with other cellular components. This research not only sheds light on the fundamental biology of inositol phosphates but also paves the way for developing novel therapeutic strategies that could manipulate IHPK1 activity in disease contexts. The ongoing investigation into IHPK1 is expected to yield significant insights into its role in cellular regulation and pathophysiology, ultimately contributing to the advancement of targeted therapies for conditions associated with dysregulated inositol phosphate metabolism.
