Analytical Data
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Gene name
FGFR-3
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简介
FGFR-3 is a member of the fibroblast growth factor receptor family and is expressed in tissues such as cartilage, brain, intestine and kidney. FGFR-3 regulates chondrocyte differentiation and proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 is a tumor marker. FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant cynomolgus-derived FGFR-3 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts, the ED50 for this effect is typically 3.693 ng/mL, corresponding to a specific activity is 2.71×105 units/mg. Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts, the ED50 for this effect is typically 3.693 ng/mL, corresponding to a specific activity is 2.71×105 units/mg.
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Alternative Names
Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
F7FZR9
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Expression Region
E23-G375
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AA Sequence
ESLGTEQRVVGRVAEVSGPEPSQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGAGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQLVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAG
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Protein Length
Partial
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Molecular Weight
55-77 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FGFR3 (Fibroblast Growth Factor Receptor 3) is a receptor tyrosine kinase that plays a crucial role in bone development and growth regulation. Mutations in the FGFR3 gene are associated with a variety of skeletal dysplasias, most notably achondroplasia, which is the most common form of human dwarfism. The study of FGFR3 recombinant proteins is essential for understanding the molecular mechanisms underlying these conditions and for developing potential therapeutic interventions. Researchers have focused on producing FGFR3 as a recombinant protein to investigate its structure-function relationships, signaling pathways, and interactions with other molecules. This recombinant protein serves as a valuable tool for elucidating the effects of specific mutations and for screening small molecules or biologics that can modulate FGFR3 activity. Given the receptor's involvement in both normal and pathological bone growth, FGFR3 recombinant protein research holds promise not only for enhancing our understanding of skeletal disorders but also for advancing drug development efforts aimed at correcting the dysregulated signaling pathways associated with FGFR3 mutations. Furthermore, these studies can pave the way for targeted therapies that could improve treatment outcomes for patients with FGFR3-related disorders. Overall, FGFR3 recombinant protein research is significant for both basic science and clinical applications, highlighting the intricate connections between genetics, protein function, and disease management.
