Analytical Data
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基因名
NELFB
- Application
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别名
Cofactor of BR;CA1
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WX92
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表达区间
8-199aa
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分子量
48.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NELFB (Negative Elongation Factor B) is a crucial protein involved in the regulation of gene expression at the transcriptional level. It plays a significant role in RNA polymerase II (Pol II) elongation by interacting with other factors and modulating transcriptional pauses. The expression and activity of NELFB have been linked to various cellular processes, including cellular growth, differentiation, and response to stress. The dysfunction of NELFB has been implicated in several diseases, including cancers and neurodegenerative disorders, making it a potential target for therapeutic interventions. Studying NELFB and its interactions with other transcriptional machinery components can provide valuable insights into the fundamental mechanisms of gene transcription and regulation. Recent advancements in recombinant protein technology enable the production of NELFB in controlled laboratory settings, facilitating detailed structural and functional studies. This research is essential for understanding the molecular basis of its actions in normal cellular physiology and pathological conditions, and it may lead to the development of novel strategies for modulating NELFB activity in disease contexts.
