Analytical Data
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Gene name
Tenascin/Tnc
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简介
Tenascin/Tnc proteins guide neuronal and axonal migration and contribute to development, synaptic plasticity, and neuronal regeneration.Tenascin/Tnc protein, Mouse (HEK293, His-Myc) is the recombinant mouse-derived Tenascin/Tnc protein, expressed by HEK293 , with N-10*His, C-Myc labeled tag.
- Application
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Alternative Names
Tenascin; TN; Hexabrachion; Tenascin-C (TN-C)
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Species
Mouse
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Source
HEK293
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Tag
N-10*His;C-Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q80YX1
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Expression Region
G1884-N2099
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AA Sequence
GLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSN
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Protein Length
Partial
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Molecular Weight
27-31 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tenascin-C (TNC) is an extracellular matrix glycoprotein that plays a crucial role in various biological processes, including cell adhesion, migration, and tissue remodeling. Its expression is particularly prominent during embryonic development and in wound healing, making it a significant factor in tissue repair and regeneration. Researchers have been investigating TNC's potential implications in various pathological conditions, such as cancer metastasis, where altered TNC expression is often observed. Additionally, TNC has been implicated in neurodevelopmental disorders and autoimmune diseases. The use of recombinant TNC (rTNC) proteins in research offers an invaluable tool for studying the protein's functional roles and interactions in these contexts. By producing rTNC in controlled laboratory conditions, scientists can explore its effects on cell behavior, signaling pathways, and the overall extracellular matrix environment. This research contributes to a deeper understanding of TNC's involvement in health and disease, potentially paving the way for therapeutic approaches targeting TNC-related pathologies. Furthermore, advancements in recombinant protein technology enable the generation of specific TNC isoforms, facilitating more precise studies on its diverse functions. Overall, the study of recombinant Tenascin-C proteins is pivotal for elucidating the molecular mechanisms underlying TNC's roles in development, disease, and regeneration.
