Analytical Data
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基因名
WTAP
- Application
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别名
hFL(2)D; Pre-mRNA-Splicing Regulator WTAP; Female-lethal(2)D homolog; WT1-associated protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15007
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表达区间
Met1~Asp150
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分子量
21kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WTAP (Wilms' tumor 1-associating protein) is an essential component of the RNA splicing machinery and plays a crucial role in the regulation of RNA metabolism. It is known for its involvement in the processing of mRNA and its functions in the biogenesis of small nuclear ribonucleoproteins (snRNPs). Studies have increasingly shown that WTAP is implicated in various biological processes, including cell proliferation, differentiation, and response to stress. Abnormal expression or mutations in the WTAP gene are linked to several types of human cancers, highlighting its potential as a therapeutic target and biomarker. Given its multifaceted roles in tumorigenesis and the regulation of alternative splicing events, the research on WTAP recombinant protein has gained significant attention. Scientists aim to characterize the protein’s structure and functional domains to understand its interactions with other splicing factors and RNA molecules. Furthermore, investigating WTAP's post-translational modifications and their effects on its activity might reveal new regulatory mechanisms in RNA processing. The development of WTAP recombinant protein could facilitate high-throughput screening of small molecules or antibodies for cancer therapeutics and provide insights into RNA biology, which may lead to novel strategies for disease intervention. Thus, WTAP serves as a promising candidate for further study in the field of molecular biology and oncology.
