Analytical Data
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Gene name
GRK4
- Application
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Alternative Names
GPRK2L; GPRK4; GRK4a; IT11; G protein-coupled receptor kinase GRK4
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32298
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Expression Region
Phe187~Phe449
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GRK4 (G protein-coupled receptor kinase 4) is a member of the GRK family involved in the phosphorylation and desensitization of G protein-coupled receptors (GPCRs), which play a crucial role in numerous physiological processes. Research on GRK4 has gained significant attention due to its association with various cardiovascular diseases, hypertension, and renal function regulation. Genetic variations in the GRK4 gene induce changes in its expression and activity, which have been implicated in altered vascular responses and abnormal blood pressure regulation. Additionally, GRK4's unique regulatory mechanisms contribute to the development of drug resistance in cancer therapies and other pathophysiological conditions. The study of GRK4 recombinant proteins offers insights into the structure-function relationships of this kinase, enabling the exploration of its regulatory role in GPCR signaling pathways. Understanding GRK4's interactions with specific receptor types and its downstream signaling cascades can pave the way for developing targeted therapies aimed at modulating its activity, therefore providing potential avenues for treatment in related diseases. As a result, the comprehensive analysis of GRK4 recombinant proteins not only enhances our fundamental knowledge of GPCR regulation but also has implications for therapeutic applications, making it a pivotal focus in both molecular biology and pharmacology research.
