Analytical Data
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基因名
PSMB2
- Application
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别名
Macropain subunit C7-IMulticatalytic endopeptidase complex subunit C7-IProteasome component C7-I
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49721
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表达区间
1-201aa
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分子量
49.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMB2, or Proteasome Subunit Beta 2, is a crucial component of the 26S proteasome, a multi-subunit protease complex responsible for degrading ubiquitinated proteins and regulating various cellular processes, including the cell cycle, apoptosis, and antigen processing. Research into PSMB2 has gained momentum due to its integral role in protein homeostasis and implications in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Mutations or dysregulation of PSMB2 have been linked to altered proteasome activity, hence affecting cellular functions and contributing to pathophysiological conditions. Given its significance, PSMB2 is a promising target for therapeutic interventions aimed at modulating proteasome activity. Moreover, the study of recombinant PSMB2 protein has provided insights into its structure, function, and interactions with other proteasome components, enabling the development of potent proteasome inhibitors and enhancing our understanding of proteostasis mechanisms. Consequently, exploring PSMB2 at a molecular level could provide novel strategies for disease treatment and inform the design of drugs that selectively modulate proteasomal functions.
