Analytical Data
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Gene name
HER4
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简介
HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, hFc) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15303-1
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Expression Region
Q26-P651
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Protein Length
Extracellular Domain
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Molecular Weight
100-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HER4, also known as ErbB4, is a member of the epidermal growth factor receptor (EGFR) family, which plays a crucial role in various biological processes, including cell proliferation, differentiation, and survival. This receptor is particularly significant in the context of cancer research, as it is implicated in the progression of several malignancies, including breast and lung cancer. Unlike its counterparts, HER1, HER2, and HER3, HER4 exhibits unique functions due to its alternative splicing, leading to the production of various isoforms that can have diverse and context-dependent roles in tumor biology. The study of HER4 recombinant proteins has gained traction in recent years, with researchers focusing on elucidating the mechanisms by which HER4 contributes to oncogenic signaling pathways. Additionally, recombinant HER4 proteins serve as valuable tools for investigating receptor interactions, downstream signaling pathways, and potential therapeutic interventions. The development of targeted therapies aimed at modulating HER4 activity offers promising prospects for enhancing cancer treatment regimens. Understanding HER4's function at a molecular level not only provides insights into its role in tumorigenesis but also uncovers potential biomarkers for patient stratification and novel therapeutic targets in oncology. The ongoing research into HER4 recombinant proteins is expected to bridge gaps in knowledge and help devise new strategies for combating HER4-positive tumors.
