Analytical Data
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基因名
KIR2DS4
- Application
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别名
CD158I; KIR1D; KIR412; KKA3; NKAT8; PAX; Cl-39; Natural killer-associated transcript 8; CD158 antigen-like family member I; NK receptor CL-39/CL-17
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43632
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表达区间
Gln22~Ser302
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分子量
32kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
KIR2DS4, a member of the Killer Immunoglobulin-like Receptor (KIR) family, plays a crucial role in the immune response, specifically in the activation of natural killer (NK) cells. KIR2DS4 is particularly interesting due to its ability to recognize and bind to HLA-C molecules, influencing NK cell activity and potentially impacting various diseases, including viral infections, cancer, and autoimmune disorders. The receptor exhibits a significant polymorphism, leading to various alleles that can affect its expression and functionality in different populations. Understanding the structure and function of KIR2DS4 is essential for unraveling its role in immune regulation and disease susceptibility. By engineering recombinant KIR2DS4 proteins, researchers aim to study its binding mechanisms, signaling pathways, and interaction with HLA molecules in controlled experiments. Such studies can provide insights into how variations in KIR2DS4 affect immune responses and may guide the development of therapeutic strategies that harness NK cell activity against tumors or enhance immune responses in infectious diseases. Overall, the investigation of KIR2DS4 recombinant proteins not only expands our knowledge of NK cell biology but also has potential implications for personalized medicine and the design of innovative immunotherapies.
