Analytical Data
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基因名
KIR3DL1
- Application
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别名
CD158E; HLA-BW4-specific inhibitory NK cell receptor; CD158 antigen-like family member E; Natural killer-associated transcript 3; p70 NK receptor CL-2/CL-11
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43629
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表达区间
Pro164~Arg437
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分子量
66kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR3DL1 is a member of the Killer Immunoglobulin-like Receptor (KIR) family, primarily expressed on natural killer (NK) cells and a subset of T cells. It plays a crucial role in the immune response by recognizing specific ligands, such as HLA-B alleles, thereby influencing the activation and inhibition of NK cell functions. Studies have linked KIR3DL1 to various immune-related disorders, including autoimmune diseases, viral infections, and cancer, making it a significant target for therapeutic interventions. The heterogeneity of KIR3DL1 expression among individuals, along with its polymorphic nature, has implications for transplant outcomes and disease susceptibility. Consequently, recombinant protein studies of KIR3DL1 enhance our understanding of its structural and functional characteristics, paving the way for potential clinical applications, such as immunotherapy or vaccine development. The investigation of KIR3DL1 recombinant proteins facilitates the exploration of its ligand interactions and signaling pathways, offering insights into its role in modulating immune responses and its potential as a biomarker for various diseases.
