Analytical Data
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基因名
COL17A1
- Application
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别名
180KDA bullous pemphigoid antigen 2Bullous pemphigoid antigen 2
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UMD9
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表达区间
1253-1497aa
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分子量
28.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL17A1, or collagen type XVII alpha 1, is a significant component of the extracellular matrix and plays a crucial role in skin integrity and stability by forming a key part of hemidesmosomes, which anchor the epidermis to the dermis. Mutations in the COL17A1 gene are associated with a rare genetic skin disorder known as epidermolysis bullosa, characterized by extreme skin fragility and blistering. Understanding the molecular mechanisms underlying COL17A1 function is vital for developing targeted therapies. Recombinant COL17A1 protein research has gained attention as it allows for the detailed investigation of its structural and functional properties, providing insights into how mutations disrupt its normal function. Additionally, recombinant COL17A1 can serve as a potential therapeutic agent in regenerative medicine and tissue engineering, offering hope for patients suffering from COL17A1-related conditions. Studies involving COL17A1 recombinant proteins also assist in creating model systems to test new treatment strategies and improve our overall understanding of collagen-based disorders.
