Analytical Data
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Gene name
PS2
- Application
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Alternative Names
PSEN2; AD3L; AD4; PS2; STM2; AD3LP; AD5; Alzheimer Disease 4
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O88777
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Expression Region
Met1~Asp127
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Molecular Weight
16kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of PS2 (Presenilin 2) recombinant proteins is situated within the broader context of Alzheimer's disease research, where PS2 is recognized as a critical component of the gamma-secretase complex involved in the cleavage of amyloid precursor protein (APP). Mutations in the PS2 gene are linked to familial Alzheimer's disease, prompting researchers to investigate its biological functions and the molecular mechanisms underlying neurodegeneration. Recombinant protein studies provide a powerful tool for elucidating the structure-function relationship of PS2 and its role in amyloid beta production. By expressing PS2 in host systems, scientists can produce sufficient quantities of the protein for biophysical characterization, functional assays, and interaction studies with other cellular components. This approach not only enhances our understanding of PS2's involvement in the pathogenesis of Alzheimer's disease but also opens avenues for therapeutic interventions aimed at modulating its activity. Additionally, PS2 recombinant proteins are invaluable in investigating the impact of specific mutations on protein function, thus shedding light on the molecular basis of disease etiology. Overall, the exploration of PS2 recombinant proteins stands at the intersection of molecular biology and neurodegenerative disease research, paving the way for innovative strategies to combat Alzheimer's disease.
