Analytical Data
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Gene name
ERK2
- Application
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Alternative Names
MAPK1; P38; P40; ERK2; ERT1; MAPK2; P42MAPK; P42-MAPK; PRKM1; PRKM2; P41; P41mapk; P41-mapk; Mitogen-Activated Protein Kinase 1; Mitogen-activated protein kinase 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28482
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Expression Region
Tyr25~Ser360
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Molecular Weight
43kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Extracellular signal-regulated kinase 2 (ERK2), part of the mitogen-activated protein kinase (MAPK) signaling pathway, plays a pivotal role in regulating various cellular processes, including proliferation, differentiation, and survival. Its activation is triggered by upstream signaling molecules in response to growth factors and stress, leading to the phosphorylation of numerous downstream substrates. Research on ERK2 recombinantly expressed protein has gained significant attention due to its involvement in key cellular functions and its implications in various diseases, including cancer, where aberrant ERK signaling is often observed. Understanding ERK2’s structure, function, and regulatory mechanisms is critical for elucidating its role in pathophysiology and developing targeted therapeutic strategies. The recombinant production of ERK2 allows for detailed biochemical and biophysical studies, facilitating the exploration of its interactions with other proteins and small molecules. Moreover, generating specific mutants of ERK2 can aid in dissecting the intricacies of its signaling pathway. This research not only contributes to basic scientific knowledge but also holds promise for identifying novel drug targets and biomarkers in diseases associated with ERK2 dysregulation, making it a focal point in biomedical research.
