Analytical Data
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基因名
GRb
- Application
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别名
GR-B
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04150#P04150-2
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表达区间
Leu528~Ile742
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of GRB (Growth Factor Receptor-Bound Protein) recombinant proteins has garnered significant attention in the field of cellular signaling and cancer research due to their pivotal role in mediating the signaling pathways of receptor tyrosine kinases. GRB proteins are essential adaptors that facilitate the transduction of growth factor signals, influencing various cellular processes such as proliferation, differentiation, and survival. In particular, GRB2 (Growth Factor Receptor-Bound protein 2) has been extensively studied for its involvement in the Ras signaling pathway, a critical pathway that, when dysregulated, can lead to tumorigenesis. Recombinant technology allows researchers to produce GRB proteins in a controlled manner, making it easier to investigate their function, interactions, and regulatory mechanisms. This research is crucial for developing targeted therapies, as understanding the structure and function of these proteins can lead to novel approaches for cancer treatment. Additionally, the use of GRB recombinant proteins in experimental settings provides valuable insights into cellular communication and the molecular underpinnings of various diseases, paving the way for advancements in precision medicine and therapeutic interventions.
