Analytical Data
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基因名
CK15
- Application
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别名
KRT15; K15, CK15, K1CO; KRTB; Keratin 15; Keratin-15,Basic; Keratin-15,Beta; Keratin, type I cytoskeletal 15
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19012
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表达区间
Val274~Leu399
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分子量
16kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK15, also known as cytokeratin 15, is a type of intermediate filament protein that plays a crucial role in the structural integrity of epithelial tissues, particularly in stratified and keratinizing epithelia. Its expression is predominantly observed in the epithelial cells of hair follicles, the cornea, and in certain types of cancers, such as squamous cell carcinoma. The study of CK15 recombinant protein has gained significance in recent years due to its potential applications in understanding epithelial cell differentiation, tissue regeneration, and cancer biology. Researchers have been particularly interested in elucidating the role of CK15 in maintaining the stemness of epithelial progenitor cells, as well as its involvement in the mechanical properties of tissues. As a recombinant protein, CK15 can be produced in vitro, allowing for more extensive studies on its biochemical properties and interactions with other cellular components. This has opened new avenues for investigating targeted therapies in cancer treatment and regenerative medicine, highlighting the need to develop robust methodologies for CK15 production, characterization, and functional assays. Overall, the research surrounding CK15 recombinant protein is pivotal for advancing our understanding of epithelial dynamics and for exploring new therapeutic strategies in tissue engineering and cancer treatment.
