Analytical Data
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Gene name
HNRPA2B1
- Application
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Alternative Names
hnRNP-A2/B1; hnRNPA2B1; RA33; HnRNPA2/B1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22626
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Expression Region
Arg21~Gly103
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Molecular Weight
10/13/14kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRPA2B1, part of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a crucial role in RNA processing and regulation, influencing mRNA splicing, stability, and transport. This protein is implicated in various cellular processes, including gene expression regulation and the maintenance of RNA integrity. Research has shown that HNRPA2B1 is involved in the pathogenesis of several diseases, including neurodegenerative disorders such as Alzheimer's disease, where it may contribute to the accumulation of toxic RNA species. The protein's ability to bind various RNA molecules allows it to participate in diverse cellular pathways, making it a key target for understanding RNA-related diseases. Given its significance, studying the recombinant HNRPA2B1 protein can provide insights into its structure-function relationship and interactions with RNA and other cellular components. Such studies are essential for elucidating the mechanisms underlying the involvement of HNRPA2B1 in health and disease, thereby paving the way for potential therapeutic interventions targeting its RNA-binding affinities and regulatory functions.
