Analytical Data
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基因名
EXO5
- Application
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别名
Defects in morphology protein 1 homolog
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H790
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表达区间
1-373aa
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分子量
57.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXO5, a member of the exosome complex, plays a crucial role in RNA metabolism, particularly in the degradation and processing of RNA molecules. The study of EXO5 has gained significance due to its involvement in various cellular processes, including gene expression regulation and the maintenance of RNA homeostasis. Research has shown that dysfunction of EXO5 can lead to several diseases, including neurodegenerative disorders and cancers, making it a potential target for therapeutic interventions. The recombinant expression of EXO5 in various systems allows for detailed studies of its structure and function, providing insights into its enzymatic mechanisms and interaction with other cellular components. This research is fundamental for understanding the broader implications of RNA metabolism in health and disease, emphasizing the necessity of investigating EXO5's biophysical properties and its regulatory pathways. Furthermore, advancements in recombinant DNA technology enhance the ability to produce EXO5 in quantities sufficient for functional assays and structural studies, paving the way for novel approaches in drug discovery and the development of RNA-targeted therapies. Consequently, the exploration of EXO5 as a recombinant protein not only clarifies its biological significance but also opens new avenues for clinical applications and the understanding of RNA biology.
