Analytical Data
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Gene name
EXO5
- Application
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Alternative Names
Defects in morphology protein 1 homolog
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H790
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Expression Region
1-373aa
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Molecular Weight
57.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EXO5, a member of the exosome complex, plays a crucial role in RNA metabolism, particularly in the degradation and processing of RNA molecules. The study of EXO5 has gained significance due to its involvement in various cellular processes, including gene expression regulation and the maintenance of RNA homeostasis. Research has shown that dysfunction of EXO5 can lead to several diseases, including neurodegenerative disorders and cancers, making it a potential target for therapeutic interventions. The recombinant expression of EXO5 in various systems allows for detailed studies of its structure and function, providing insights into its enzymatic mechanisms and interaction with other cellular components. This research is fundamental for understanding the broader implications of RNA metabolism in health and disease, emphasizing the necessity of investigating EXO5's biophysical properties and its regulatory pathways. Furthermore, advancements in recombinant DNA technology enhance the ability to produce EXO5 in quantities sufficient for functional assays and structural studies, paving the way for novel approaches in drug discovery and the development of RNA-targeted therapies. Consequently, the exploration of EXO5 as a recombinant protein not only clarifies its biological significance but also opens new avenues for clinical applications and the understanding of RNA biology.
