Analytical Data
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基因名
Aconitase 1/ACO1
- Application
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别名
IREB1; IRP1; IREBP; Iron regulatory protein 1; Iron-responsive element-binding protein 1; Cytoplasmic aconitate hydratase; Citrate hydro-lyase; Ferritin repressor protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P21399
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表达区间
Pro251~Pro443
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Aconitase 1 (ACO1) is an essential enzyme in the citric acid cycle, playing a critical role in cellular energy production by catalyzing the reversible conversion of citrate to isocitrate. Beyond its metabolic function, ACO1 has been implicated in various cellular processes, such as iron homeostasis and oxidative stress response. Research has indicated that ACO1 can function as a signaling molecule, influencing gene expression and cellular growth under conditions of stress, particularly in cancer and neurodegenerative diseases. Given its multifaceted roles, the recombinant production of ACO1 has garnered interest for therapeutic and diagnostic applications. By utilizing recombinant DNA technology, scientists can produce ACO1 in a controlled manner, which enables the study of its structure-function relationships, enzymatic activity, and interaction with other cellular components. Additionally, understanding the molecular mechanisms by which ACO1 operates could lead to novel insights into its regulation and the potential development of targeted therapies for diseases linked to its dysregulation. Thus, the study of recombinant ACO1 not only furthers our comprehension of fundamental metabolic pathways but also opens avenues for biotechnological advancements in health and disease management.
