Analytical Data
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基因名
IFITM3/Fragilis
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简介
IFITM3/Fragilis protein, a member of the IFITM family, has antiviral properties. It impedes the entry of viral pathogens, including influenza A, Ebola, and SARS-CoV-2, into cells. This protein is ubiquitously expressed in various tissues, such as the liver (RPKM 370.9) and placenta (RPKM 358.2), among others. IFITM3/Fragilis Protein, Human (HEK293, Fc) is the recombinant human-derived IFITM3/Fragilis protein, expressed by HEK293 , with N-mFc labeled tag.
- Application
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别名
Interferon-induced transmembrane protein 3; DSPA2b; Interferon-inducible protein 1-8U
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种属
Human
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表达系统
HEK293
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标签
N-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01628
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表达区间
M1-H57
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蛋白长度
Cytoplasmic Domain
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分子量
33-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFITM3 (Interferon-Inducible Transmembrane Protein 3) and Fragilis are proteins that have garnered significant attention within the fields of immunology and virology. IFITM3 is known for its role in the innate immune response, particularly in the restriction of viral infections, acting as a barrier to various pathogens, including influenza and HIV. It is upregulated in response to interferon signaling, indicating its importance as a frontline defense mechanism during viral challenges. On the other hand, Fragilis, a protein that is often associated with cellular adhesion and communication, is involved in processes such as cell migration, which plays a crucial role in tissue repair and immune responses. Recent studies have highlighted the potential of IFITM3 and Fragilis in modulating immune responses and their implications for vaccine development and therapeutic interventions in viral diseases. Research involving recombinant proteins of IFITM3 and Fragilis aims to elucidate their functional mechanisms, interaction networks, and structural properties, providing deeper insights into their roles in immune regulation and potential applications in enhancing host defense against infections. This exploration not only deepens our understanding of viral pathogenesis but also paves the way for innovative approaches to tackle infectious diseases, making IFITM3 and Fragilis promising candidates for further investigation in both fundamental and applied biological research.
