Analytical Data
-
Gene name
CTRC
-
简介
CTRC proteins critically regulate trypsinogen and procarboxypeptidase, precisely cleaving their zymogen precursors to influence activation and degradation. Its chymotrypsin-type protease activity helps control enzyme processing. CTRC Protein, Human (HEK293, His) is the recombinant human-derived CTRC protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
-
Alternative Names
rHuChymotrypsin-C/CTRC, His; Chymotrypsin-C; Caldecrin; CTRC; CLCR
-
Species
Human
-
Source
HEK293
-
Tag
C-6*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q99895
-
Expression Region
C17-L268
-
AA Sequence
CGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
-
Protein Length
Full Length of Mature Protein
-
Molecular Weight
33-40 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of CTRC (Cationic Trypsinogen-Related Cysteine-Proteinase) recombinant proteins has gained significance in the context of pancreatic diseases, particularly acute pancreatitis and pancreatic cancer. CTRC, a serine protease inhibitor, plays a crucial role in regulating digestive enzyme activation within the pancreas, preventing premature activation that can lead to tissue damage. Mutations in the CTRC gene have been implicated in hereditary pancreatitis, underscoring the protein’s role in disease pathology. Researchers have focused on producing recombinant CTRC proteins to elucidate their structural and functional properties, enabling better understanding of their mechanisms in pancreatic physiology and pathology. These studies aim to investigate the interaction of CTRC with other proteases and its potential as a therapeutic target. Moreover, recombinant CTRC proteins serve as vital tools for developing novel diagnostic and therapeutic strategies in managing pancreatic disorders, thereby contributing to improved patient outcomes. As the prevalence of pancreatic diseases continues to rise, the exploration of CTRC and its recombinant forms becomes increasingly relevant for both basic and applied biomedical research.
