Analytical Data
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基因名
PPIL2
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简介
PPIL2 exhibits ubiquitin-protein ligase activity, acting as an E3 ligase or ubiquitin-ubiquitin ligase, promoting “Lys-48”-linked polyubiquitination for proteasomal degradation of substrates.It acts as a chaperone to help transport BSG/Basigin to the cell membrane.PPIL2 Protein, Human (His) is the recombinant human-derived PPIL2 protein, expressed by E.coli , with N-His labeled tag.
- Application
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别名
RING-type E3 ubiquitin-protein ligase PPIL2; CYC4; Cyp60; Rotamase PPIL2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13356-2
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表达区间
G280-P457
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蛋白长度
Partial
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPIL2 (Peptidyl-Prolyl Isomerase Like 2) is a member of the cyclophilin family of proteins, which are known to catalyze the isomerization of proline residues in polypeptides, influencing protein folding and stability. Emerging research has highlighted the potential roles of PPIL2 in various cellular processes, including signal transduction, cell proliferation, and apoptosis. Notably, PPIL2 has been implicated in the regulation of immune responses and may play a significant role in cancer biology, as its expression is often altered in tumors. The study of PPIL2 as a recombinant protein provides valuable insights into its biochemical properties and functional mechanisms. By producing and characterizing PPIL2 in a recombinant form, researchers can investigate its interactions with other proteins, identify potential binding partners, and elucidate its role in various biological pathways. This research could pave the way for targeted therapies that modulate PPIL2 activity, offering new avenues for treating diseases associated with its dysregulation. Understanding the structure-function relationship of PPIL2 through recombinant protein studies is crucial, as it may unveil novel therapeutic targets and enrich our comprehension of cellular functionality in health and disease.
