Analytical Data
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Gene name
PPIL2
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简介
PPIL2 exhibits ubiquitin-protein ligase activity, acting as an E3 ligase or ubiquitin-ubiquitin ligase, promoting “Lys-48”-linked polyubiquitination for proteasomal degradation of substrates.It acts as a chaperone to help transport BSG/Basigin to the cell membrane.PPIL2 Protein, Human (His) is the recombinant human-derived PPIL2 protein, expressed by E.coli , with N-His labeled tag.
- Application
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Alternative Names
RING-type E3 ubiquitin-protein ligase PPIL2; CYC4; Cyp60; Rotamase PPIL2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13356-2
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Expression Region
G280-P457
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Protein Length
Partial
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPIL2 (Peptidyl-Prolyl Isomerase Like 2) is a member of the cyclophilin family of proteins, which are known to catalyze the isomerization of proline residues in polypeptides, influencing protein folding and stability. Emerging research has highlighted the potential roles of PPIL2 in various cellular processes, including signal transduction, cell proliferation, and apoptosis. Notably, PPIL2 has been implicated in the regulation of immune responses and may play a significant role in cancer biology, as its expression is often altered in tumors. The study of PPIL2 as a recombinant protein provides valuable insights into its biochemical properties and functional mechanisms. By producing and characterizing PPIL2 in a recombinant form, researchers can investigate its interactions with other proteins, identify potential binding partners, and elucidate its role in various biological pathways. This research could pave the way for targeted therapies that modulate PPIL2 activity, offering new avenues for treating diseases associated with its dysregulation. Understanding the structure-function relationship of PPIL2 through recombinant protein studies is crucial, as it may unveil novel therapeutic targets and enrich our comprehension of cellular functionality in health and disease.
