Analytical Data
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Gene name
CDK19-CCNC-MED12
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简介
CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication[1][2][3]. CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK19-CCNC-MED12, expressed by Sf9 insect cells , with N-6*His, N-GST, N-Flag labeled tag. ,
- Application
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Species
Human
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Source
Baculovirus
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Tag
N-6*His;N-GST;N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BWU1-1 (M1-Y502)&P24863-1 (M1-S283)&Q93074-1
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Expression Region
Q9BWU1-1 (M1-Y502)&P24863-1 (M1-S283)&Q93074-1 (M1-D100)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK19-CCNC-MED12 is a notable protein complex that plays a critical role in transcription regulation and cellular processes. CDK19, a cyclin-dependent kinase, is closely associated with the Mediator complex, of which MED12 is a vital component. This complex is essential for the proper functioning of RNA polymerase II, facilitating the transcription of various genes involved in cell growth and differentiation. CCNC, or cyclin C, further enhances the regulatory capabilities of the complex, connecting cell cycle control with transcriptional regulation. Dysregulation of this protein complex has been implicated in several diseases, including cancers and developmental disorders, where aberrant expression can lead to uncontrolled cell proliferation. Research into the structure, function, and interaction dynamics of CDK19-CCNC-MED12 is crucial for understanding its role in normal cellular physiology as well as its implications in disease states. Identifying specific inhibitors or modulators of this complex could pave the way for novel therapeutic strategies aimed at restoring normal transcriptional regulation in pathologies associated with its dysfunction. As such, the exploration of CDK19-CCNC-MED12 not only enhances our understanding of gene expression mechanisms but also opens new avenues in biomedical research and drug development.
