Analytical Data
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Gene name
PGD2 Synthase/PTGDS
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简介
The PGD2 synthase/PTGDS protein converts PGH2 to PGD2, which regulates smooth muscle and inhibits platelet aggregation.It affects central nervous system functions including sedation, NREM sleep, and potential anti-apoptotic effects on oligodendrocytes.PGD2 Synthase/PTGDS Protein, Rat (HEK293, His) is the recombinant rat-derived PGD2 Synthase/PTGDS protein, expressed by HEK293 , with C-His, C-6*His labeled tag.
- Application
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Alternative Names
Prostaglandin-H2 D-isomerase; L-PGDS; PGDS2; PTGDS
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Species
Rat
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P22057
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Expression Region
Q25-E189
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Protein Length
Full Length of Mature Protein
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Molecular Weight
26-29 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Prostaglandin D2 synthase (PGD2 synthase), also known as PTGDS, is an important enzyme involved in the biosynthesis of prostaglandin D2 (PGD2), a bioactive lipid mediator that plays a crucial role in various physiological and pathological processes, including inflammation, sleep regulation, and allergic responses. PGD2 is synthesized from prostaglandin H2 (PGH2) and functions through specific receptors, influencing diverse cellular activities. Abnormal PGD2 levels have been implicated in several diseases, including asthma, Alzheimer’s disease, and various allergic conditions. The recombinant expression of PGD2 synthase offers a valuable tool for studying its biochemical properties and regulatory mechanisms. By producing the enzyme in a controlled laboratory environment, researchers can dissect its function, explore its interactions with other biomolecules, and develop potential therapeutic interventions targeting PGD2 pathways. Additionally, functional studies using recombinant PGD2 synthase can provide insights into its role in physiological processes and disease mechanisms. The advancements in recombinant protein technology have facilitated the generation of large quantities of purified PTGDS, allowing for extensive characterization and study, which is essential for understanding its contributions to health and disease.
