Analytical Data
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基因名
ATF2
- Application
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别名
Activating transcription factor 2;Cyclic AMP-responsive element-binding protein 2 ;CREB-2 ;cAMP response element-binding protein CRE-BP1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15336
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表达区间
1-505aa
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分子量
70.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATF2 (Activating Transcription Factor 2) is a key player in cellular responses to stress and is involved in various physiological processes, including cell proliferation, differentiation, and apoptosis. As a member of the ATF/CREB family of transcription factors, ATF2 can be activated by several stress-related signaling pathways, such as MAPK pathways, which respond to environmental stresses like UV radiation, heat shock, and oxidative stress. Dysregulation of ATF2 has been implicated in various diseases, including cancer, where it can influence tumor growth and metastasis. Research into the structure and function of recombinant ATF2 protein has gained momentum in recent years as scientists aim to elucidate its molecular mechanisms and understand its role in gene expression regulation. By studying the recombinant protein, researchers can investigate its binding affinities, post-translational modifications, and interactions with other cellular proteins. Additionally, recombinant ATF2 is also explored for its potential as a therapeutic target or biomarker in cancer treatment and other stress-related disorders. Understanding the detailed biology of ATF2 through recombinant protein studies is crucial for developing novel therapeutic strategies aimed at modulating its activity in pathological conditions, ultimately contributing to improved disease management and patient outcomes.
