Analytical Data
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Gene name
CDK13-CCNT1
- Application
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Alternative Names
CDC2L5; CHED; CDC2L; CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cholinesterase-Related Cell Division Controller
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14004
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Expression Region
Phe705~Leu998
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK13 (Cyclin-Dependent Kinase 13) is a pivotal serine/threonine kinase that plays a crucial role in regulating transcription and RNA processing. It forms a complex with CCNT1 (Cyclin C-Activated Kinase 1), a member of the cyclin family, which modulates the transcriptional elongation of various genes. Abnormalities in CDK13, including mutations and overexpression, have been linked to several cancers and developmental disorders, highlighting its importance in cellular processes and potential as a therapeutic target. The CDK13-CCNT1 complex is essential for the phosphorylation of RNA polymerase II, influencing gene expression and mRNA maturation. Studies have indicated that targeting this complex could modulate gene expression patterns in cancer cells, offering new avenues for treatment strategies. Understanding the structure and function of the CDK13-CCNT1 recombinant protein can provide insights into its biological roles, mechanisms of action, and interactions with other cellular components. Investigating the CDK13-CCNT1 complex at the molecular level could uncover its regulatory functions and potential implications in oncogenesis, thereby contributing to the development of novel therapeutic interventions for tumor-related diseases. Additionally, characterizing this protein complex could enhance our understanding of the broader networks involved in cell cycle regulation and transcriptional control, paving the way for integrative approaches in cancer research and treatment.
