Analytical Data
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Gene name
C1D
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简介
The C1D protein has multifunctionality in cellular processes, recruiting RNA exosome complexes for 5.8S rRNA processing, possibly in conjunction with MPHOSPH6. It activates PRKDC with linear and supercoiled DNA and induces apoptosis through the p53/TP53 pathway. C1D Protein, Human (His) is the recombinant human-derived C1D protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Alternative Names
Nuclear nucleic acid-binding protein C1D; hC1D; C1D
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q13901
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Expression Region
M1-S141
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Protein Length
Full Length
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C1D protein, a member of the C1D family of proteins, has garnered attention in molecular biology and biomedical research due to its multifunctional roles in cellular processes. Initially identified for its involvement in the regulation of gene expression, C1D is known to interact with DNA and RNA, suggesting a role in transcriptional regulation and nuclear processes. Recent studies have highlighted its significance in various cellular pathways, including stress response and apoptosis, making it a potential focus in cancer research and therapy. Furthermore, C1D has been implicated in the modulation of chromatin structure, which is essential for gene accessibility and expression. Its expression levels have been correlated with several malignancies, indicating its potential as a biomarker for diagnosis and prognosis. The recombinant version of C1D protein has become an important tool for elucidating its biochemical properties and physiological functions. By utilizing advanced techniques in protein engineering and purification, researchers are exploring C1D's roles in cellular signaling pathways and its interactions with other cellular components. Understanding the mechanisms by which C1D operates could unveil novel therapeutic strategies for diseases where these pathways are disrupted, thereby addressing significant gaps in current medical treatments. As research on C1D protein continues to unfold, it holds promise not only for expanding our understanding of cellular biology but also for its application in developing targeted therapeutic interventions.
