Analytical Data
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Gene name
Can f 6
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简介
Can f 6 is a novel dog lipid allergen that cross-reacts with horse and cat lipids. Can f 6 and homologous allergens may cause multiple sensitization and symptoms in individuals allergic to mammals. Can f 6 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 6 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Lipocalin Can f 6.0101; Allergen Can f 6
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Species
Canine
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
H2B3G5
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Expression Region
H16-E190
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Protein Length
Full Length of Mature Protein
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Molecular Weight
22-27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Can f 6 is a major allergen derived from dog saliva, recognized for its significant role in canine allergenicity and its association with pet dander-induced allergic reactions in sensitized individuals. As a member of the lipocalin protein family, Can f 6 exhibits a unique structure that facilitates the binding and transport of small volatile molecules, which may influence the allergenic potential. Research has revealed that Can f 6 can trigger immunological responses, leading to symptoms such as asthma, rhinitis, and skin allergies in susceptible individuals. With the increasing prevalence of pet ownership worldwide, understanding the molecular mechanisms underlying Can f 6's allergenicity is crucial for developing effective diagnostics and targeted immunotherapies. Current studies focus on characterizing its biochemical properties, elucidating its interaction with immune cells, and exploring potential strategies for hypoallergenic pet breeds. This research is pivotal in providing insights into not only pet-related allergies but also broader mechanisms of allergic responses, ultimately contributing to improved management of allergic diseases associated with canine allergens.
