Analytical Data
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Gene name
HLA-DRA1*01:01&DRB1*11:01&CLIP (PVSKMRMATPLLMQA) Monomer
- Application
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Alternative Names
HLA-DRA1*0101 & HLA-DRB1*1101 & CLIP (PVSKMRMATPLLMQA)
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
CAI2388006.1 (I26-E216)&CAI2388099.1
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Expression Region
CAI2388006.1 (I26-E216)&CAI2388099.1 (G30-K227)&PVSKMRMATPLLMQA
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Molecular Weight
38-42 kDa and 34-37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-DRA1*01:01 and DRB1*11:01 are polymorphic alleles of the human leukocyte antigen (HLA) system, which plays a crucial role in the immune response by presenting peptides to T cells. The HLA-DR molecule, a type of major histocompatibility complex (MHC) class II protein, is essential for the activation of CD4+ T cells, making it integral to adaptive immunity. The CLIP (Class II-associated invariant chain peptide) sequence, represented by the peptide PVSKMRMATPLLMQA, serves as a placeholder that stabilizes the MHC class II structure during its assembly and transport to the cell surface. Research on the monomeric form of the HLA-DRA1*01:01 and DRB1*11:01 complex in conjunction with CLIP is important for understanding the molecular mechanisms of antigen presentation and T cell activation. This study aims to elucidate how different alleles of HLA-DR interact with CLIP and how these interactions influence immune responses in populations, particularly in relation to autoimmune diseases and transplant compatibility. By investigating the structural and functional characteristics of this recombinant protein, researchers hope to advance therapeutic strategies in immunology, as well as provide insights into the genetic basis of immune responses in various diseases.
