Analytical Data
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Gene name
CSNK1E
- Application
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Alternative Names
Casein kinase 1 epsilon; Casein kinase I; Casein kinase I epsilon; Casein kinase I isoform epsilon; CKI epsilon; CKI-epsilon; CKIe; CKIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; HCK IE; KC1E; KC1E_HUMAN; kinase CK1 epsilon; MGC 10398
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49674
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Expression Region
17-231aa
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Molecular Weight
51.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1E, or Casein Kinase 1 Epsilon, is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, circadian rhythm regulation, and Wnt signaling pathways. Mutations or dysregulation of CSNK1E have been linked to several diseases, including cancer and neurodegenerative disorders such as Alzheimer's disease. Due to its involvement in critical signaling pathways, CSNK1E has garnered significant interest as a potential therapeutic target. Research on recombinant CSNK1E protein has enabled scientists to investigate its biochemical properties, substrate specificity, and regulatory mechanisms. The production of recombinant CSNK1E allows for detailed studies of its kinase activity, interaction with other proteins, and its role in cellular signaling networks. Understanding the precise function of CSNK1E can shed light on its contributions to disease processes and facilitate the development of targeted therapies. Moreover, the recombinant protein can be used in high-throughput screening assays to identify inhibitors or modulators, paving the way for novel pharmacological interventions. In summary, the study of CSNK1E recombinant protein is vital for elucidating its biological functions and potential as a drug target, highlighting its importance in both fundamental research and clinical applications.
