Analytical Data
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基因名
GFAP
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简介
The GFAP protein is a member of the class III intermediate filament family and serves as a cell-specific marker critical for distinguishing astrocytes from other glial cells in the developing central nervous system. Its role as a marker is critical in defining the identity of astrocytes, highlighting their unique characteristics in a complex cellular environment. GFAP Protein, Mouse (His-SUMO) is the recombinant mouse-derived GFAP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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别名
Glial fibrillary acidic protein; GFAP
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种属
Mouse
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表达系统
E. coli
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标签
N-6*His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P03995
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表达区间
M1-M430
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氨基酸序列
MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQKLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKDSKQEHKDVVM
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蛋白长度
Full Length
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分子量
65.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Glial fibrillary acidic protein (GFAP) is a key intermediate filament protein predominantly expressed in astrocytes, a type of glial cell in the central nervous system. It plays a crucial role in maintaining the structural integrity and function of astrocytes, contributing to the blood-brain barrier, and participating in neuroinflammatory processes. Research into recombinant GFAP has gained momentum due to its potential significance in neurological disorders. Elevated GFAP levels in cerebrospinal fluid and serum are associated with various conditions such as Alzheimer's disease, multiple sclerosis, and traumatic brain injury, making it a promising biomarker for diagnosis and monitoring disease progression. The production of recombinant GFAP enables detailed studies of its molecular structure, interactions, and functional properties in vitro and in vivo, facilitating the exploration of its role in astrocyte activation and neuroinflammation. Additionally, recombinant GFAP can be utilized in therapeutic approaches and drug development, as it may help elucidate the mechanisms underlying astrocyte-related pathologies. Overall, the study of GFAP and its recombinant forms is vital for advancing our understanding of glial cell biology and its implications in health and disease.
