Analytical Data
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Gene name
CaMKII beta/CAMK2B
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简介
CaMKII beta/CAMK2B is a calcium/calmodulin-dependent protein kinase that functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. It plays an important role in dendritic spine and synapse formation, neuronal plasticity, and the regulation of skeletal muscle sarcoplasmic reticulum Ca(2+) transport. CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is the recombinant human-derived CaMKII beta/CAMK2B, expressed by Sf9 insect cells, with GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is 665 a.a..
- Application
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Alternative Names
Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13554-1
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Expression Region
A2-Q666
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CaMKII beta (CAMK2B) is a critical serine/threonine kinase that plays a pivotal role in various cellular processes, particularly in the modulation of synaptic plasticity and learning and memory functions in neurons. As a member of the CaMKII family, CAMK2B is activated by calcium and calmodulin, leading to its autophosphorylation and subsequent activation of downstream signaling pathways. Research into CAMK2B has expanded significantly due to its implications in neurological disorders and cardiovascular diseases. Abnormalities in CAMK2B expression or function can be linked to conditions such as Alzheimer’s disease, schizophrenia, and heart failure, making it a target for therapeutic interventions. The study of recombinant CAMK2B protein is crucial for understanding its structure-function relationships, regulatory mechanisms, and interaction with other signaling molecules. This research can enhance our insights into its role in cellular signaling and contribute to the development of targeted treatments that might mitigate the effects of diseases associated with CAMK2B dysregulation. Moreover, the production of recombinant CAMK2B has provided a valuable tool for biochemical assays and structural biology studies, facilitating the exploration of this kinase's physiological and pathological roles. Overall, the research on CaMKII beta is not only significant for basic biology but also holds promise for clinical applications, making it a focal point of ongoing scientific investigation.
