Analytical Data
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基因名
VRK1
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简介
The VRK1 protein is a serine/threonine kinase that complexly regulates the cell cycle, nuclear condensation, and transcription. It critically induces Golgi disassembly during the cell cycle via PLK3 phosphorylation, thereby affecting Golgi fragmentation. VRK1 Protein, Human (sf9) is the recombinant human-derived VRK1 protein, expressed by Sf9 insect cells, with tag free.
- Application
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别名
Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1; VRK1
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99986
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表达区间
Q99986 (N-G&P, M1-K396)
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蛋白长度
Full Length
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VRK1 (vaccinia-related kinase 1) is a serine/threonine kinase that plays a critical role in cell proliferation, differentiation, and stress response. Its significance in cellular processes has drawn attention due to its involvement in various biological functions, particularly in the regulation of the cell cycle and response to DNA damage. Studies have demonstrated that VRK1 can phosphorylate key substrates, influencing signaling pathways that are crucial for cellular homeostasis. Moreover, aberrant expression or mutation of VRK1 has been implicated in several diseases, including cancer, where it may contribute to uncontrolled proliferation and progression of tumors. Research into VRK1 recombinant protein aims to unravel its functional mechanisms and potential as a therapeutic target. By producing VRK1 in a recombinant form, scientists can investigate its enzymatic activity, substrate specificity, and interaction with other proteins in a controlled environment. This research is essential for elucidating the kinase's role in pathophysiological conditions and could lead to novel strategies for disease intervention, highlighting the importance of VRK1 in both basic biology and clinical applications.
