Analytical Data
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基因名
TREM-2
- Application
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别名
Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; TREM2
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZC2-1
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表达区间
H19-S174
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分子量
55-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TREM-2, or Triggering Receptor Expressed on Myeloid Cells 2, is a receptor primarily found on myeloid cells such as microglia and macrophages, playing a crucial role in immune response and neuroinflammation. Recent studies have highlighted its importance in neurodegenerative diseases, particularly Alzheimer's disease, where TREM-2 is implicated in modulating microglial activation and response to amyloid-beta plaques. The receptor enhances the clearance of apoptotic cells and promotes tissue repair, indicating its potential as a therapeutic target. However, the mechanisms underlying TREM-2 signaling remain partially understood. Recombinant TREM-2 proteins are instrumental in elucidating these pathways, allowing researchers to investigate its interactions, ligand-binding dynamics, and downstream effects on cellular responses. Furthermore, there is growing interest in the potential of TREM-2 as a biomarker for neurodegeneration, making recombinant proteins vital for developing diagnostic and therapeutic strategies. Understanding TREM-2 functions and modulation through recombinant protein studies could pave the way for innovative treatments in diseases characterized by chronic inflammation and neuronal damage.
