Analytical Data
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Gene name
Glypican-1/GPC1
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简介
Glypican-1 (GPC1) is a heparan sulfate-containing cell surface proteoglycan. Glypican-1/GPC1 Protein, Human (S486A, S488A, S490A, HEK293, His) is the recombinant human-derived Glypican-1/GPC1 protein, expressed by HEK293, with C-His labeled tag.
- Application
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Alternative Names
rHuGlypican-1/GPC1, His; Glypican-1; GPC1
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35052-1
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Expression Region
D24-S530, S486A, S488A, S490A
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Molecular Weight
58-61 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Glypican-1 (GPC1) is a heparan sulfate proteoglycan that plays a crucial role in various cellular processes, including growth factor signaling, cell adhesion, and the modulation of the extracellular matrix. Research has shown that GPC1 is implicated in several human diseases, particularly in cancer, where its overexpression is often correlated with tumor progression and metastasis. This has sparked interest in GPC1 as a potential biomarker for early cancer detection and a therapeutic target. The recombinant protein form of GPC1 is essential for studying its functional properties and mechanisms of action. By producing GPC1 as a recombinant protein, researchers can examine its interactions with other molecules, evaluate its role in cellular signaling pathways, and assess its potential use in targeted therapies or as an antigen in vaccine development. Furthermore, the understanding of GPC1's structure and function can provide insights into its role in normal physiology and pathological conditions, paving the way for novel therapeutic strategies. The ongoing research into GPC1 and its recombinant forms underscores the importance of this molecule in biomedical science and its potential for clinical applications in cancer and other diseases.
