Analytical Data
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基因名
ZBTB17
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简介
The ZBTB17 protein is a multifunctional transcription factor that functions as a binding partner-based activator or repressor and a targeted regulator of cell cycle progression. It is essential for early lymphocyte development, preventing apoptosis and ensuring lineage commitment. ZBTB17 Protein, Human (His) is the recombinant human-derived ZBTB17 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Zinc Finger and BTB Domain-Containing Protein 17; Myc-Interacting Zinc Finger Protein 1; Miz-1; Zinc Finger Protein 151; Zinc Finger Protein 60; ZBTB17; MIZ1; ZNF151; ZNF60
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13105
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表达区间
M1-A188
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氨基酸序列
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADA
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蛋白长度
Partial
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分子量
18.0-26.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZBTB17, a member of the ZBTB (zinc finger and BTB domain-containing) family of proteins, has garnered significant interest due to its potential role in various biological processes, including transcriptional regulation, cell differentiation, and immune responses. It is implicated in the regulation of gene expression and chromatin remodeling, which are critical for maintaining cellular homeostasis and lineage specificity. Recent studies have suggested that ZBTB17 may also play a role in cancer biology, particularly in the maintenance of cancer stem cells and tumor progression. Understanding its structure and function through recombinant protein studies is essential for elucidating its biological roles. The ability to produce ZBTB17 as a recombinant protein allows researchers to investigate its interactions with DNA, other proteins, and cellular pathways in a controlled environment. Furthermore, exploring the post-translational modifications of ZBTB17 can provide insights into its regulation and functional implications in health and disease. The study of ZBTB17 not only advances our knowledge of fundamental biological mechanisms but also offers potential therapeutic avenues for targeting its dysregulation in cancer and other diseases. As such, the production and characterization of ZBTB17 recombinant protein are critical steps in this ongoing research endeavor.
