Analytical Data
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Gene name
TSH alpha/beta Heterodimer
- Application
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Alternative Names
TSH alpha/beta Heterodimer; TSH; Thyrotropin
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01215-1 (A25-S116)& P01222-1
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Expression Region
P01215-1 (A25-S116)& P01222-1 (F21-V138)
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Molecular Weight
43-48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Thyroid-stimulating hormone (TSH) is a vital glycoprotein hormone composed of two subunits, alpha and beta, which together form a functional heterodimer. The alpha subunit is shared among several glycoprotein hormones, including luteinizing hormone (LH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG), while the beta subunit is unique to TSH and is responsible for its specificity in stimulating the thyroid gland. The recombinant production of TSH alpha/beta heterodimeric proteins has gained significant interest due to its potential applications in both basic and clinical research, particularly in understanding thyroid function and disorders such as hypothyroidism and hyperthyroidism. Traditional methods of obtaining TSH are often limited by ethical concerns and low yield, making recombinant proteins an attractive alternative. Researchers are exploring various expression systems, including yeast, bacterial, and mammalian cell lines, to produce biologically active TSH heterodimers. These studies aim to elucidate the structure-function relationships of TSH and how it interacts with its receptor, TSR, advancing our knowledge of thyroid physiology and providing insights for therapeutic interventions. Furthermore, the availability of recombinant TSH can facilitate the development of new diagnostic tools and treatments for thyroid-related diseases, thereby contributing to improved patient care. The ongoing research into recombinant TSH alpha/beta heterodimers underscores the critical intersection of biotechnology and endocrinology, highlighting the importance of understanding hormonal signaling pathways for innovative medical solutions.
