Analytical Data
-
Gene name
FOXP3
-
简介
FOXP3 is a key transcriptional regulator essential for the development and function of regulatory T cells (Tregs), ensuring immune system homeostasis. It acts as a dual repressor and activator, regulating Treg suppressive function and stability while affecting conventional T cell expansion. FOXP3 Protein, Human (431a.a, His) is the recombinant human-derived FOXP3 protein, expressed by E. coli, with N-His labeled tag.
- Application
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9BZS1-1
-
Expression Region
M1-P431
-
Molecular Weight
51-53 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FOXP3, or Forkhead Box P3, is a crucial transcription factor that plays a vital role in the regulation of immune responses, particularly in the development and function of regulatory T cells (Tregs). The gene encoding FOXP3 is located on the X chromosome, and mutations in this gene can lead to immunological disorders, such as autoimmune diseases and severe combined immunodeficiency in humans. Given its importance in maintaining immune tolerance and preventing autoimmunity, the study of FOXP3 has garnered significant interest in both immunology and therapeutic research. Recombinant FOXP3 protein is often produced for various experimental purposes, including structural studies, functional assays, and the development of targeted therapies. Research involving FOXP3 aims to elucidate its structural characteristics, understand the molecular mechanisms governing its function, and explore its potential as a biomarker for immunological diseases or targets for immunotherapy. Additionally, FOXP3's involvement in cancer immunology is an emerging area of investigation, as it can influence tumor microenvironments and T cell responses in various malignancies. Overall, the recombinant production of FOXP3 protein is a pivotal step in advancing our understanding of immune regulation and developing innovative therapeutic strategies for treating immune-related disorders.
