Analytical Data
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Gene name
Raptin
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简介
Raptin a sleep-inducible hypothalamic protein hormone that suppresses obesity. Raptin is cleaved from reticulocalbin-2 (RCN2). Raptin release is timed by the circuit from vasopressin-expressing neurons in the suprachiasmatic nucleus to RCN2-positive neurons in the paraventricular nucleus. Raptin Protein, Human (His) is a recombinant Raptin protein expressed by E.coli with an N-His tag.
- Application
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Alternative Names
RCN2; reticulocalbin-2; Raptin; E6BP; ERC55
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14257
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Expression Region
S28-P249
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Molecular Weight
29.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Raptin, a recently identified protein, plays a significant role in cellular processes, particularly in the modulation of signaling pathways involved in cell proliferation and survival. Its research background is rooted in the quest to understand the intricate mechanisms of intracellular signaling, especially how various proteins interact to influence cellular behavior. Preliminary studies have highlighted Raptin's involvement in key pathways such as the PI3K/Akt and MAPK pathways, which are crucial for regulating cell growth and metabolism. Moreover, aberrations in these signaling pathways are often linked to various diseases, including cancer. Understanding Raptin's function and its potential interactions can provide insights into its role in disease progression and offer avenues for therapeutic interventions. Recent advances in proteomics and molecular biology have paved the way for in-depth studies of Raptin, aiming to elucidate its structural characteristics, binding partners, and functional implications in health and disease. As researchers continue to investigate Raptin, its potential as a biomarker or a target for drug development could significantly impact therapeutic strategies for conditions associated with dysregulated cell signaling.
