Analytical Data
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基因名
TRIM5
- Application
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别名
TRIM5α; TRIM5alpha; TRIM5-alpha; RNF88; RING finger protein 88
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9C035
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表达区间
Ala2~Thr261
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分子量
36kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIM5 is a member of the tripartite motif (TRIM) family of proteins, which play crucial roles in various cellular processes, including immune response and protein degradation. One of the most fascinating aspects of TRIM5 is its role in innate immunity, particularly in recognizing and inhibiting retroviral infections, such as those caused by HIV. The protein contains a RING domain, B-box, and coiled-coil region, which contribute to its function as an antiviral factor. The study of TRIM5 has gained significant attention due to its ability to bind directly to the capsid of incoming retroviruses, leading to their destabilization and preventing successful infection. Interestingly, different primate species exhibit variations in TRIM5 alleles, leading to differences in susceptibility to various retroviruses, providing valuable insights into evolutionary biology and host-pathogen interactions. Research on TRIM5 recombinant proteins aims to elucidate their mechanisms of action and potential therapeutic applications, such as developing antiviral strategies or enhancing immune responses against retroviral infections. Additionally, TRIM5 has been implicated in modulating several cellular pathways, including autophagy and inflammation, thereby highlighting its multifunctional nature. Overall, the exploration of TRIM5 recombinant proteins is crucial not only for understanding the intricacies of viral recognition and resistance but also for paving the way toward novel biomedical interventions in the fight against viral diseases.
