Analytical Data
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Gene name
ROR1
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简介
ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q01973
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Expression Region
M453-N783
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Protein Length
Partial
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Molecular Weight
55-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) is a protein that plays a critical role in various cellular processes, including embryonic development and stem cell maintenance. Its expression is largely restricted to embryonic tissues and certain types of cancer cells, making it an attractive target for cancer immunotherapy. Research has shown that ROR1 is overexpressed in several malignancies, including chronic lymphocytic leukemia (CLL), breast cancer, and lung cancer, while being minimally present in normal adult tissues. This unique expression pattern has spurred interest in developing ROR1-targeted therapies, particularly recombinant proteins such as monoclonal antibodies and chimeric antigen receptors (CARs). These developments aim to harness the immune system to specifically recognize and eliminate ROR1-positive cancer cells, potentially reducing off-target effects and improving treatment efficacy. Additionally, ROR1's involvement in signaling pathways that promote tumorigenesis underscores its relevance in cancer biology. Current studies are focusing on understanding the molecular mechanisms governing ROR1's function and its potential as a biomarker for prognosis and treatment response. Overall, the exploration of ROR1 and its recombinant forms holds promise for advancing precision medicine strategies in oncology.
