Analytical Data
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基因名
EphB6
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简介
EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293, His) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB8
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15197-1
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表达区间
L32-S594
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蛋白长度
Extracellular Domain
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分子量
60-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphB6 is a member of the Eph receptor tyrosine kinase family, which plays a crucial role in cell signaling processes governing developmental and physiological functions, particularly in the nervous system. Unlike other Eph receptors, EphB6 exhibits a unique characteristic of functioning mainly as a negative regulator of cell signaling pathways. This regulation is significant in various biological contexts, including cell proliferation, differentiation, and migration, particularly in neural tissues. Research has indicated that EphB6 may be implicated in tumor biology, as its expression levels might influence cancer progression and metastasis. In the context of neurodegenerative diseases, EphB6's role in modulating synaptic functions and neuronal interactions presents a potential therapeutic target. The recombinant production of EphB6 protein is essential for studying its biochemical properties, interactions with ligands, and downstream signaling mechanisms. Such studies can facilitate a deeper understanding of its biological roles and may pave the way for novel therapeutic strategies in treating diseases where EphB6's function is altered. Therefore, characterizing EphB6 in detail through recombinant protein technology is vital for elucidating its potential implications in health and disease.
