Analytical Data
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Gene name
HIPK1
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简介
HIPK1 is a multifunctional serine/threonine protein kinase that complexly regulates transcriptional control and TNF-mediated apoptosis. It acts as a corepressor for homeodomain transcription factors and regulates gene expression by phosphorylating the substrates DAXX and MYB. HIPK1 Protein, Human (sf9) is the recombinant human-derived HIPK1 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
HIPK1; Homeodomain-interacting protein kinase 1; Nuclear body-associated kinase 2
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86Z02
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Expression Region
T158-I555
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HIPK1 (homeodomain-interacting protein kinase 1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. It has been implicated in multiple signaling pathways, particularly in the context of cancer and developmental biology. Dysregulation of HIPK1 has been associated with various malignancies, which highlights its potential as a therapeutic target. Recent studies have revealed that HIPK1 also interacts with several transcription factors, modulating their activity and influencing gene expression. This multifaceted role makes HIPK1 a significant focus of research in understanding tumorigenesis and developing targeted therapies. The production of recombinant HIPK1 protein is essential for studying its biochemical properties, understanding its interactions with other proteins, and elucidating its mechanism of action. By utilizing recombinant technology, researchers can obtain large quantities of pure HIPK1, facilitating structural and functional analysis. These studies aim to unravel the pathways involved in HIPK1-related diseases and to identify potential inhibitors that could serve as novel cancer treatments. Overall, the investigation of HIPK1 and its recombinant form holds promise for advancing our knowledge of its biological roles and therapeutic applications.
