Analytical Data
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Gene name
TAOK2
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简介
TAOK2 is a multifunctional serine/threonine protein kinase that affects membrane blebbing, apoptotic body formation, DNA damage response, and the MAPK14/p38 MAPK cascade. It exhibits broad substrate specificity and can phosphorylate itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulin. TAOK2 Protein, Human (sf9, GST) is the recombinant human-derived TAOK2 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
TAOK2; Serine/threonine-protein kinase TAO2; Kinase from chicken homolog C; hKFC-C; Prostate-derived sterile 20-like kinase 1; PSK-1; PSK1; Prostate-derived STE20-like kinase 1; Thousand and one amino acid protein kinase 2
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UL54
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Expression Region
M1-K314
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAOK2 (TAO kinase 2) is a member of the TAO family of serine/threonine kinases, which play critical roles in various cellular processes, including stress response, apoptosis, and oncogenesis. Recent studies have shown that TAOK2 is involved in the regulation of signaling pathways related to neurodevelopment and synaptic plasticity, making it a potential candidate in understanding neuropsychiatric disorders and developmental delinquencies. Dysregulation of TAOK2 has been linked to conditions such as autism spectrum disorders and schizophrenia, highlighting its importance in psychiatric research. As a result, the recombinant expression of TAOK2 has garnered attention to elucidate its structural and functional characteristics. By producing TAOK2 as a recombinant protein, researchers aim to investigate its kinase activity, substrates, and interactions with other signaling molecules, which could lead to therapeutic insights and targets for drug development. Additionally, understanding the post-translational modifications of TAOK2 may provide further insights into its regulatory mechanisms and the pathological conditions associated with its dysfunction. Overall, the study of recombinant TAOK2 holds promise for advancing our knowledge of its biological significance and potential as a therapeutic target in neurodevelopmental and psychiatric disorders.
