Analytical Data
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基因名
EphB1
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简介
EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived EphB1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6
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种属
Mouse
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8CBF3-1
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表达区间
M591-A984
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蛋白长度
Partial
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphB1 is a member of the Eph receptor family, which encompasses a subclass of receptor tyrosine kinases known for their roles in mediating cell-cell interactions during developmental processes and tissue homeostasis. This receptor is particularly involved in pathways related to neuronal development, angiogenesis, and immune responses. Its interacting ephrin ligands, particularly ephrin-Bs, facilitate bidirectional signaling essential for various physiological functions. Aberrant EphB1 signaling has been implicated in multiple diseases, including cancer, where it may contribute to processes such as tumor progression and metastasis. Thus, understanding the structure and function of EphB1 has significant implications for therapeutic strategies. Research involving EphB1 recombinant protein has gained traction as it allows for the elucidation of its biological activities and molecular mechanisms. The production of EphB1 in a recombinant form enables detailed studies of its ligand interactions, signaling pathways, and potential as a target for drug development. Furthermore, the characterization of EphB1 through recombinant protein studies can shed light on its role in pathological conditions, opening avenues for innovative treatments based on modulation of EphB1 signaling. Given the complexity of its functions and the critical nature of its signaling in developmental and pathological contexts, continuous research on EphB1 remains vital for advancing our understanding of its contributions to health and disease.
