Analytical Data
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Gene name
EphA3
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简介
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA3 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Ephrin type-A receptor 3; EPH-like kinase 4; hEK4; EPHA3; ETK; ETK1; HEK; TYRO4
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8BRB1
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Expression Region
M1-H541
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Protein Length
Partial
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Molecular Weight
96 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA3 is a member of the Eph receptor family, which are the largest subfamily of receptor tyrosine kinases. These receptors play critical roles in regulating cell-cell interactions, as well as mediating cell adhesion, migration, and tissue organization during embryonic development and in adult tissues. Given their involvement in various physiological processes, EphA3 has garnered attention for its potential implications in cancer biology, particularly in tumorigenesis and metastasis. Overexpression of EphA3 has been associated with several types of cancers, making it a promising biomarker and therapeutic target. Researchers are focusing on the development of EphA3 recombinant proteins to facilitate the study of its structural and functional properties, alongside its interaction with ligands known as ephrins. By investigating the signaling pathways activated by EphA3, as well as its role in tumor progression, scientists aim to uncover novel insights into cancer treatment. The engineering of EphA3 recombinant proteins allows for detailed studies, helping to elucidate the receptor's mechanisms and potential as a target for drug development, providing a pathway towards innovative cancer therapies and advancing understanding of receptor-mediated signaling in pathological conditions.
