Analytical Data
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基因名
EphA3
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简介
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Human (sf9, GST) is the recombinant human-derived EphA3, expressed by Sf9 insect cells, with GST labeled tag. The total length of EphA3 Protein, Human (sf9, GST) is 405 a.a..
- Application
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别名
EPHA3; Eph receptor A3; ephrin type-A receptor 3; EK4; EPH-like kinase 4; tyrosine-protein kinase TYRO4; tyrosine-protein kinase receptor ETK1; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
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种属
Human
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表达系统
Baculovirus
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标签
GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29320-1
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表达区间
K579-V983
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蛋白长度
Partial
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分子量
71.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA3 is a member of the Eph receptor family, which are the largest subfamily of receptor tyrosine kinases. These receptors play critical roles in regulating cell-cell interactions, as well as mediating cell adhesion, migration, and tissue organization during embryonic development and in adult tissues. Given their involvement in various physiological processes, EphA3 has garnered attention for its potential implications in cancer biology, particularly in tumorigenesis and metastasis. Overexpression of EphA3 has been associated with several types of cancers, making it a promising biomarker and therapeutic target. Researchers are focusing on the development of EphA3 recombinant proteins to facilitate the study of its structural and functional properties, alongside its interaction with ligands known as ephrins. By investigating the signaling pathways activated by EphA3, as well as its role in tumor progression, scientists aim to uncover novel insights into cancer treatment. The engineering of EphA3 recombinant proteins allows for detailed studies, helping to elucidate the receptor's mechanisms and potential as a target for drug development, providing a pathway towards innovative cancer therapies and advancing understanding of receptor-mediated signaling in pathological conditions.
