Analytical Data
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Gene name
RIZ1
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简介
RIZ1 Protein, an S-adenosyl-L-methionine-dependent histone methyltransferase, specifically methylates 'Lys-9' of histone H3. Additionally, it acts as a DNA-binding transcription factor, showing affinity for the MTE within the HMOX1 gene. Implicated as a potential activator, RIZ1 suggests a regulatory role in HMOX1 gene expression beyond histone modification. RIZ1 Protein, Human is the recombinant human-derived RIZ1 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
PR domain zinc finger protein 2; MTB-ZF; Zinc finger protein RIZ; PRDM2; KMT8; RIZ
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13029
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Expression Region
M1-A200
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Protein Length
Partial
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIZ1, or Retinoblastoma-interacting Zinc Finger protein 1, is a member of the PRDM family of proteins that has garnered attention for its role in epigenetic regulation and tumor suppression. Research indicates that RIZ1 functions as a transcriptional regulator by promoting the expression of key genes involved in cell differentiation and growth inhibition. Its zinc finger domains facilitate binding to specific DNA sequences, underpinning its regulatory functions. Studies have shown that RIZ1 is frequently downregulated or lost in various malignancies, suggesting its critical role in preventing oncogenesis. The reintroduction of RIZ1 into cancer cell lines has demonstrated a capacity to induce cell cycle arrest and apoptosis, highlighting its potential as a therapeutic target. Furthermore, investigations into RIZ1's interplay with other tumor suppressors and oncogenes are revealing intricate networks of signaling pathways impacting cancer development. The recombinant expression of RIZ1 protein in vitro allows for detailed studies of its biochemical properties and functional mechanisms, which can facilitate the development of innovative cancer therapies. Understanding the molecular dynamics of RIZ1 offers promising avenues for harnessing its anti-cancer properties, making it a significant subject of research in oncology and molecular biology.
