Analytical Data
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基因名
CDKL2
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简介
Cyclin-dependent kinase-like 2 (CDKL2), is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression and is a regulator of epithelial-mesenchymal transition (EMT). CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders[1][2]. CDKL2 Protein, Human (sf9, His) is the recombinant human-derived CDKL2 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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别名
Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; CDKL2
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种属
Human
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92772
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表达区间
M1-H493
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蛋白长度
Full Length
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分子量
63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDKL2 (Cyclin-dependent kinase-like 2) is a serine/threonine kinase that plays a crucial role in regulating cellular processes such as cell cycle progression, neuronal differentiation, and synaptic transmission. Mutations and dysregulation of CDKL2 have been implicated in various neurodevelopmental disorders, including intellectual disability and epilepsy. Given its significant role in neuronal function, the study of CDKL2 recombinants has garnered interest for potential therapeutic applications. Recombinant CDKL2 proteins are essential for elucidating the structure-function relationships of this kinase, as well as for exploring its biological pathways. Advances in recombinant protein technology allow researchers to produce CDKL2 in sufficient quantities for biochemical assays, enabling the investigation of its enzymatic activity and interactions with other cellular components. Understanding the biophysical properties and regulatory mechanisms of CDKL2 may lead to novel insights into its role in disease pathology and identify biomarkers for early diagnosis and therapeutic targets. Therefore, the study of CDKL2 recombinant proteins is not only pivotal for basic neurological research but also holds promise for developing innovative treatment strategies for conditions associated with CDKL2 dysfunction.
