Analytical Data
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Gene name
CAMKI gamma/CAMK1G
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简介
The CAMK1G protein is a calcium/calmodulin-dependent protein kinase and a key component of the proposed calcium-triggered signaling cascade. This kinase exhibits the ability to phosphorylate the transcription factor CREB1 in vitro, suggesting its involvement in regulating cellular processes related to gene expression and transcriptional control. CAMKI gamma/CAMK1G Protein, Human (sf9, His, GST) is the recombinant human-derived CAMKI gamma/CAMK1G protein, expressed by Sf9 insect cells , with His, GST labeled tag.
- Application
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Alternative Names
Calcium/calmodulin-dependent protein kinase type 1G; CaMKI gamma; CLICK III; CLICK3; VWS1
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Species
Human
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Source
Baculovirus
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Tag
His;GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96NX5-1
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Expression Region
M1-M476
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMK1G, or Calcium/Calmodulin-dependent protein kinase I gamma, is a critical serine/threonine kinase that plays a significant role in various cellular processes, including calcium signaling, cell cycle regulation, and neuronal functions. As a member of the calcium/calmodulin-dependent protein kinase (CaMK) family, CAMK1G is activated upon binding to calcium-bound calmodulin, leading to phosphorylation of target proteins that modulate signal transduction pathways. Research has indicated its involvement in neuronal differentiation and synaptic plasticity, making it a potential candidate for studying neurological disorders. The interest in recombinant CAMK1G protein has surged, driven by the need to understand its precise molecular mechanisms and functional roles in health and disease. By producing this kinase in a recombinant form, researchers can investigate its enzymatic activities, interaction with substrates, and effects on signaling pathways in more controlled settings. This approach could aid in elucidating CAMK1G's contribution to various pathophysiological conditions, including neurodegenerative diseases and cancer, where altered calcium signaling and kinase activity are often implicated. The generation of recombinant CAMK1G protein not only facilitates functional assays and structural studies but also enhances the potential for therapeutic interventions targeting this kinase pathway. Overall, the study of CAMK1G and its recombinant protein offers promising avenues for advancing our understanding of cellular signaling networks and developing novel therapeutic strategies.
