Analytical Data
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基因名
ADAMTS14
- Application
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别名
(ADAM-TS 14)(ADAM-TS14)(ADAMTS-14)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WXS8
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表达区间
253-555aa
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分子量
40.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAMTS14 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 14) is a member of the ADAMTS family, which plays a significant role in extracellular matrix remodeling and regulation of various biological processes. Research on ADAMTS14 has gained traction due to its implications in several pathological conditions, including osteoarthritis and intervertebral disc degeneration, where it is believed to influence the degradation of cartilage and extracellular matrix components. In addition to its role in tissue homeostasis, ADAMTS14 has been linked to inflammatory responses and cellular signaling pathways. The recombinant expression of ADAMTS14 protein allows for detailed studies on its enzymatic activity, substrate specificity, and regulatory mechanisms, thus providing insights into its functional roles in health and disease. By producing this protein in a controlled manner, researchers can explore its interactions with other matrix proteins and elucidate its potential as a therapeutic target. Understanding the structure-function relationship of ADAMTS14 at the molecular level may contribute to the development of novel treatments for diseases associated with extracellular matrix dysregulation. This research holds promise not only for advancing our comprehension of matrix biology but also for leveraging ADAMTS14 as a biomarker or therapeutic agent in related clinical applications.
